Can’t wake them, seizure, or trouble breathing? Call 911 (U.S.)Overdose response
Substance library

NON-OPIOID SEDATIVES

Xylazine and medetomidine

Xylazine and medetomidine are different sedatives found in some street opioid mixtures.

Test separately
Xylazine, medetomidine and fentanyl
Xylazine
Watch for wounds
Medetomidine
Withdrawal can be severe

Test separately and watch breathing

Use separate strips for xylazine, medetomidine, and fentanyl. Strips can miss drugs and can’t measure dose.

If someone can’t wake up or breathe normally, call 911 and give naloxone for any opioids. They may stay sleepy after breathing improves. Follow the dispatcher and stay with them.

Get help for wounds or withdrawal

Xylazine can cause wounds even away from injection sites. Get wound care early. Get urgent help for spreading redness or fever.

Medetomidine withdrawal can be severe. Get medical help if you use frequently. Call 911 for chest pain, confusion, or a racing heart after cutting down.

Sources